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The Barshop Institute for Longevity and Aging Studies
University of Texas Health San Antonio
15355 Lambda Drive
San Antonio TX 78245

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mTOR-dependent neurovascular uncoupling in Alzheimer's disease

Our recent studies show that mTOR drives impairments in neurovascular coupling in mouse models of Alzheimer's through the inhibition of neuronal (nNOS) and endothelial (eNOS) nitric oxide synthase activity.

mTOR-driven loss of vascular density and cerebral blood flow in Alzheimer's

We have identified mTOR as a key driver of cerebral blood flow deficits through vascular density loss in models of Alzheimer's disease.