Identifying molecular and biochemical alterations that cause Alzheimer's disease and other dementias

We seek to understand the processes that drive Alzheimer's disease (AD) with a focus on those that link aging to AD and other dementias, and to define the therapeutic potential of drug candidate molecules in AD.  We use  genetic manipulations in rodents, in vivo optical and MRI- and PET-based brain imaging, tissue and single-cell -omics, biochemical, physiological, and behavioral tools, as well as cellular and molecular biology approaches.  Our goal is to advance our understanding of age-associated neurological disease mechanisms and identify interventions to prevent or treat AD and other age-associated dementias.