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Welcome to the Galvan Lab

Identifying molecular and biochemical alterations that cause Alzheimer's disease and other dementias

We seek to understand the processes that drive Alzheimer's disease (AD) with a focus on those that link aging to AD and other dementias, and to define the therapeutic potential of drug candidate molecules in AD.  We use  genetic manipulations in rodents, in vivo optical and MRI- and PET-based brain imaging, tissue and single-cell -omics, biochemical, physiological, and behavioral tools, as well as cellular and molecular biology approaches.  Our goal is to advance our understanding of age-associated neurological disease mechanisms and identify interventions to prevent or treat AD and other age-associated dementias.  

Research

Brain vascular dysfunction in Alzheimer's disease

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Vascular tau in Alzheimer's and other tauopathies

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Brain vascular endothelial cell senescence in Alzheimer's disease

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Regulation of peripheral metabolism and lifespan

by neuronal mTOR

More information
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Astrocyte senescence

in Alzheimer's disease

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Mailing Address

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Department of Biochemistry and Molecular Biology
University of Oklahoma Health Sciences Center
940 Stanton L. Young Blvd, BMSB 810
Oklahoma City, OK 73104

Contact us

Phone: (405) 271-2227 ext 32778

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