Identifying molecular and biochemical alterations that cause Alzheimer's disease and other dementias

We seek to understand the processes that drive Alzheimer's disease (AD) with a focus on those that link aging to AD and other dementias, and to define the therapeutic potential of drug candidate molecules in AD.  

We use  advanced genetic manipulations in rodents, in vivo optical and MRI- and PET-based brain imaging, laser Doppler-based cerebral blood flow measures, primary cell culture systems and biochemical, cellular and molecular biology approaches, together with whole tissue and single-cell -omic and behavioral tools.  

Our goal is to advance our understanding of age-associated neurological disease mechanisms and identify interventions to prevent or treat AD and other age-associated dementias.  

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