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Welcome to the Galvan Lab

Identifying molecular and biochemical alterations that cause Alzheimer's disease and other dementias

We seek to understand the processes that drive Alzheimer's disease (AD) with a focus on those that link aging to AD and other dementias, and to define the therapeutic potential of drug candidate molecules in AD.  

We use  advanced genetic manipulations in rodents, in vivo optical and MRI- and PET-based brain imaging, laser Doppler-based cerebral blood flow measures, primary cell culture systems and biochemical, cellular and molecular biology approaches, together with whole tissue and single-cell -omic and behavioral tools.  

Our goal is to advance our understanding of age-associated neurological disease mechanisms and identify interventions to prevent or treat AD and other age-associated dementias.  

 
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Brain vascular endothelial cell senescence in Alzheimer's disease

Regulation of metabolism by neuronal mTORC1

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Astrocyte senescence in Alzheimer's disease

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Vascular tau in Alzheimer's and other tauopathies

mTOR-driven vascular dysfunction in Alzheimer's disease

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Mailing Address

Department of Biochemistry and Molecular Biology

Center for Geroscience and Healthy Brain Aging
University of Oklahoma Health Sciences Center
940 Stanton L. Young Blvd., BMSB 853
Oklahoma City, OK  73104

Contact us

Phone: (405) 271-2227

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Lab picture Zoom flat 120220

Angela Poster Japan
Angela Poster Japan

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lab pic March 2014 web site 3 copy.jpg

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Lab picture Zoom flat 120220