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Recent Publications

References and Links to Papers

Yellow dot brain

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

April 2023

Hussong SA, Banh AQ, Van Skike CE, Dorigatti, AO, Hernandez, SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V.
Nature Communications 14, 2367 (2023). 

Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer's disease

April 2023

Van Skike CE, DeRosa N, Galvan V, Hussong, SA. 

Geroscience. 2023. Epub ahead of print

PMID: 37052770

mTOR attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling Alzheimer's disease

April 2023

Van Skike CE, Hussong SA, Hernandez, SF, Banh AQ,

DeRosa N, Galvan V.
J Neurosci. 2021 41(19): 4305-4320

PMID: 33888602 

Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging

February 2021

Dorigatti AO, Hussong SA, Hernandez, SF, Sills AM, Salmon AB, Galvan V.
Geroscience. 2021 Feb; 43(1):115-124.
PMID: 33063253

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

January 2020

Van Skike CE, Lin, AL, Roberts, RB, Halloran, JJ, Hernandez, SF, Cuvillier, Soto, VY, Hussong, SA, Jahrling, JB, Javors, MA, Hart, MJ, Fischer, KE, Austad, SN, Galvan, V.

Aging Cell. 2020 Jan; 19(1):e13057

PMID: 31693798

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment

December 22, 2017 (epub)

Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari ZI, Lechleiter JD, Galvan V.
Am J Physiol Heart Circ Physiol. 2017 Dec 22. doi: 10.1152/ajpheart.00570.2017. [Epub ahead of print]
PMID: 29351469

A perfect sTORm: The role of the mammalian target of rapamycin (mTOR) in cerebrovascular dysfucntion of Alzheimer's disease: A mini-review

January 11, 2018 (epub)

Van Skike CE, Galvan V.
Gerontology. 2018 Jan 11. doi: 10.1159/000485381. [Epub ahead of print]
PMID: 29320772

January 2018

Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.
J Cereb Blood Flow Metab. 2018 Jan; 38(1):58-74.
PMID: 28511572

May 2, 2017

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging Dis. 2017 May 2;8(3):257-266. PMID: 28580182

May 25, 2016

Galvan V, Hart MJ.
Biochim Biophys Acta. 2016 May;1862(5):992-1007. Epub 2015 Nov 27.
PMID: 26639036

September 6, 2013

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.
J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21.  Epub 2013 Jun 26.
PMID: 23801246

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June 28, 2012

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.
Neuroscience. 2012 Oct 25;223:102-13. 
PMID: 22750207

April 1, 2010

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.
PLoS One. 2010 Apr 1;5(4):e9979. 
PMID: 20376313

March 14, 2013

Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V.
J Neurochem. 2013 Mar;124(6):880-93. Epub 2012 Dec 26.
PMID: 23121022

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October 13, 2013

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. Epub 2013 Jul 10.

PMID: 23838831

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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment

April 2018

Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari ZI, Lechleiter JD, Galvan V.
Am J Physiol Heart Circ Physiol. 2018 April 1; 314(4):H693-H703
PMID: 29351469

A perfect sTORm: The role of the mammalian target of rapamycin (mTOR) in cerebrovascular dysfucntion of Alzheimer's disease: A mini-review

January 2018

Van Skike CE, Galvan V.
Gerontology. 2018; 64(3):205-211
PMID: 29320772

January 2018

Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.
J Cereb Blood Flow Metab. 2018 Jan; 38(1):58-74.
PMID: 28511572

May 2017

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging Dis. 2017 May 2;8(3):257-266.

PMID: 28580182

May 2016

Galvan V, Hart MJ.
Biochim Biophys Acta. 2016 May;1862(5):992-1007. Epub 2015 Nov 27.
PMID: 26639036

September 2013

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.
J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21.  Epub 2013 Jun 26.
PMID: 23801246

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Dots 2

June 2012

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.
Neuroscience. 2012 Oct 25;223:102-13. 
PMID: 22750207

April 2010

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.
PLoS One. 2010 Apr 1;5(4):e9979. 
PMID: 20376313

March 2013

Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V.
J Neurochem. 2013 Mar;124(6):880-93. Epub 2012 Dec 26.
PMID: 23121022

Brain dots gray

October 2013

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. Epub 2013 Jul 10.

PMID: 23838831

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