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Selected Recent Publications

References and Links to Papers

April 2023

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Hussong SA, Banh AQ, Van Skike CE, Dorigatti, AO, Hernandez, SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V.

Nature Communications. 2023. 14 (1): 2367

PMID: 37185259

June 2023

Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer's disease

Van Skike CE, DeRosa N, Galvan V, Hussong, SA. 

 Geroscience 2023 45(3): 1987-1996

 PMID: 37052770

May 2021

mTOR attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling Alzheimer's disease

Van Skike CE, Hussong SA, Hernandez, SF, Banh AQ,   DeRosa N, Galvan V.

J. Neurosci. 2021. 41 (19): 4305-4320

PMID: 33888602

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies

May 2, 2017

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging Dis. 2017 May 2;8(3):257-266. PMID: 28580182

​

Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

May 25, 2016

Galvan V, Hart MJ.
Biochim Biophys Acta. 2016 May;1862(5):992-1007. Epub 2015 Nov 27.
PMID: 26639036

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease

September 6, 2013

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.
J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21.  Epub 2013 Jun 26.
PMID: 23801246

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Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

June 28, 2012

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.
Neuroscience. 2012 Oct 25;223:102-13. 
PMID: 22750207

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

April 1, 2010

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.
PLoS One. 2010 Apr 1;5(4):e9979. 
PMID: 20376313

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

March 14, 2013

Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V.
J Neurochem. 2013 Mar;124(6):880-93. Epub 2012 Dec 26.
PMID: 23121022

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Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

October 13, 2013

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. Epub 2013 Jul 10.

PMID: 23838831

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February 2021

Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging

Dorigatti AO, Hussong SA, Hernandez SF, Sills AM, Salmon AB, Galvan V.

Geroscience. 2021. 43(1): 115-124.

PMID: 33063253

 

mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment

January 2018

Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.J Cereb Blood Flow Metab. 2018 Jan; 38(1):58-74.PMID: 28511572

May 2017

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies

Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R.

Aging Dis. 2017 May 2;8(3):257-266. PMID: 28580182

​

Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

May 2016

Galvan V, Hart MJ.
Biochim Biophys Acta. 2016 May;1862(5):992-1007. Epub 2015 Nov 27.
PMID: 26639036

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease

September 2013

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.
J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21.  Epub 2013 Jun 26.
PMID: 23801246

Dots 2.png
neuron%202_edited.png

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

October 2012

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.
Neuroscience. 2012 Oct 25;223:102-13. 
PMID: 22750207

dopamine.png

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

April 2010

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.
PLoS One. 2010 Apr 1;5(4):e9979. 
PMID: 20376313

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

December 2013

Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V.
J Neurochem. 2013 Mar;124(6):880-93. Epub 2012 Dec 26.
PMID: 23121022

Brain%20dot%202_edited.png

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

October 2013

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. Epub 2013 Jul 10.

PMID: 23838831


mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

January 2020

Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V

Aging Cell. 2020 Jan; 19(1): e13057.   

PMID: 31693798

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment

Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari ZI, Lechleiter JD, Galvan V.

Am J Physiol Heart Circ Physiol. 2018. 314 (4): H693-H703.

PMID: 29351469

April 2018

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